The St. Louis County Department of Health provides resources aimed at educating residents and developing policies related to health. Its website contains a wide range of topics including disease prevention, animal control, preparation for emergencies, restaurant inspections and details about health centers throughout the county.

The building is located just north of World Trade Center Saint Louis. It contains the following offices: first floor, vital statistics (birth and death certificates); second floor, environmental health; third floor, health administration; fourth floor, crime lab; fifth floor, health lab.